In this project, we will develop an innovative protocol for adaptive stimulation in Parkinson’s disease patients. Adaptive stimulation will be based on simultaneous local field potential recordings from the basal ganglia, as well as cortical brain signals (electrocorticography).
We will use these to identify new biomarkers that will allow us to individually adapt deep brain stimulation to various symptoms and physiological activity, and include theoretical stimulation models to optimize control variables.
By the end of the funding period, we aim to provide an optimized adaptive stimulation protocol suitable for long-term recordings, which can be applied in a clinical study in the second funding period
Team
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Prof. Andrea Kühn
Charité – Universitätsmedizin Berlin
Spokesperson, Steering Committee Member, Project Leader
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Dr. Gerd-Helge Schneider
Charité – Universitätsmedizin Berlin
Project Leader
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Prof. Michael Rosenblum
Universität Potsdam
Project Leader
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Dr. Lucia Feldmann
Charité – Universitätsmedizin Berlin
Postdoc
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Erik Mau
Universität Potsdam
PhD Student
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Johannes Busch
Charité – Universitätsmedizin Berlin
Postdoc
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Jonathan Kaplan
Charité – Universitätsmedizin Berlin
MD Student
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Varvara Mathiopoulou
Charité – Universitätsmedizin Berlin
PhD Student
Publications
Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson’s Disease.
- Prof. Esther Florin
- Prof. Alfons Schnitzler
- Dr. Bahne Bahners
- Dr. Gerd-Helge Schneider
- Jonathan Kaplan
- Johannes Busch
- Prof. Andrea Kühn
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance.
- Prof. Andrea Kühn
- Prof. Hagai Bergman
- Prof. Julian Neumann
Desynchronizing two oscillators while stimulating and observing only one.
- Erik Mau
- Prof. Michael Rosenblum
Insights and opportunities for deep brain stimulation as a brain circuit intervention.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
A First Methodological Development and Validation of ReTap: An Open-Source UPDRS Finger Tapping Assessment Tool Based on Accelerometer-Data
- Dr. Rachel Spooner
- Varvara Mathiopoulou
- Dr. Lucia Feldmann
- Johannes Busch
- Dr. Bahne Bahners
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Andrea Kühn
Christmas-Related Reduction in Beta Activity in Parkinson’s Disease
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Johannes Busch
- Varvara Mathiopoulou
- Dr. Gerd-Helge Schneider
- Dr. Andreas Horn
- Prof. Andrea Kühn
- Prof. Julian Neumann
Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients.
- Dr. Roxanne Lofredi
- Dr. Gerd-Helge Schneider
- Prof. Julian Neumann
- Prof. Andrea Kühn
Inferring oscillator’s phase and amplitude response from a scalar signal exploiting test stimulation
- Erik Mau
- Prof. Michael Rosenblum
Spectral and spatial distribution of subthalamic beta peak activity in Parkinson’s disease patients.
- Dr. Natasha Darcy
- Dr. Roxanne Lofredi
- Prof. Julian Neumann
- Dr. Gerd-Helge Schneider
- Prof. Andrea Kühn
Overnight unilateral withdrawal of thalamic deep brain stimulation to identify reversibility of gait disturbances.
- Dr. Andreas Horn
- Prof. Andrea Kühn
