Area C

C03 | Closed-loop neurostimulation in MPTP monkeys

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In this project, we will assemble a comprehensive database of the functional connectivity within and between nuclei of the basal ganglia of non-human primates throughout the sleep-wake cycle, before and following MPTP intoxication and development of Parkinson’s disease. This information will enable us to design frequency- and phase-specific closed-loop deep brain stimulation therapy that adapts to the circadian rhythm and thereby improves the quality of life of upcoming generations of Parkinson’s disease patients.

Team

Publications

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