TRR 295


Insights and latest results of our research are regularly published in peer-reviewed journals. The majority of our articles are published open access to ensure the availability to a broad audience including affected people and the general lay public.

Brain-to-gut trafficking of alpha-Synuclein by CD11c+ cells in a mouse model of Parkinson’s disease.

McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, Karl AK, Pagenstecher A, Vogel J, Beilhack A, Koprich JB, Brotchie JM, Saliba AE, Volkmann J, Ip CW.

One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics.
Published: Nov 2023

Optimization of data pre-processing methods for time-series classification of electroencephalography data.

Anders C, Curio G, Arnrich B, Waterstraat G.

Here, the influence of spatial filter optimization methods and non-linear data transformation on time-series classification performance is analyzed by the example of high-frequency somatosensory evoked responses.
Published: Nov 2023

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

Neumann WJ, Steiner LA, Milosevic L


In this Update we aim to produce an integrative account of complementary instead of mutually exclusive neurophysiological effects to derive a generalizable concept of the mechanisms of deep brain stimulation.
Published: Nov 2023

Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Ayon-Olivas M, Wolf D, Andreska T, Granado N, Lüningschrör P, Ip CW, Moratalla R, Sendtner M.

In this study, we showed that the activation of DRD2 in cultured striatal indirect pathway spiny projection neurons (iSPNs) and cholinergic interneurons causes the retraction of TrkB from the plasma membrane. This provides an explanation for the opposing synaptic plasticity changes observed upon DRD1 or DRD2 stimulation.
Published: Oct 2023

Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson’s Disease.

Busch JL, Kaplan J, Bahners BH, Roediger J, Faust K, Schneider GH, Florin E, Schnitzler A, Krause P, Kühn AA.

Using novel sensing-enabled neurostimulators, we investigated local field potentials (LFPs) and their modulation by DBS to assess whether electrophysiological biomarkers may facilitate clinical programming in chronically implanted patients.
Published: Oct 2023

Prediction of Stroke Outcome in Mice Based on Noninvasive MRI and Behavioral Testing.

Knab F, Koch SP, Major S, Farr TD, Mueller S, Euskirchen P, Eggers M, Kuffner MTC, Walter J, Berchtold D, Knauss S, Dreier JP, Meisel A, Endres M, Dirnagl U, Wenger N, Hoffmann CJ, Boehm-Sturm P*, Harms C*.

Systematic analysis of stroke outcome predictors in mice is lacking. We developed a tool to predict late pellet reaching performance based on early stroke localization in a diverse cohort of 215 mice.
Published: Sep 2023