Publications

We performed multimodal analysis on 583 microelectrode recordings (MER) from PD patients undergoing DBS surgery under local anesthesia (LA) and GA.

Transcranial magnetic stimulation evoked potentials (TEPs) show promise as a biomarker in major depressive disorder (MDD), but the origin of the increased TEP amplitude in these patients remains unclear. Gamma aminobutyric acid (GABA) may be involved, as TEP peak amplitude is known to increase with GABAergic activity in healthy controls. We employed a computational modeling approach to investigate this phenomenon.

We analysed long-term tremor and gait outcomes in 73 patients from two DBS centres with chronic bilateral (sub)thalamic DBS, assessed before surgery and at follow-up after 12 months using blinded ratings of standardized video recordings. We evaluated the influence of demographic, clinical, and stimulation parameters and applied voxel-wise probabilistic stimulation mapping to identify anatomical regions associated with tremor suppression and stimulation-induced gait ataxia.

We characterize the frequency-specific reorganization of the cortical hierarchy across resting and motor states using functional gradients. We sought to identify topographic biomarkers that emerge across different behavioral states and determine whether these hierarchical features provide predictive power for global motor severity.

We investigated the impact of visual states on basal ganglia oscillatory biomarkers, comparing local field potentials (LFPs) dynamics between Parkinson's disease (PD) and dystonia and developing a decoding model for state identification.