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TRR 295

Retuning dynamic motor network disorders using neuromodulation

Research insights to improve the therapy of brain disorders by the Transregional Collaborative Research Center TRR 295 ReTune, which is funded by the German Research Foundation (DFG).

Standard of care

Developing innovative neuromodulation therapies

Many neurological diseases are associated with movement disorders. Neuromodulation, a method that applies therapeutic electric currents or magnetic fields to the brain, has demonstrably helped restore motor deficits in movement-impaired patients. While deep brain stimulation (DBS) is considered the gold standard for treating Parkinson´s disease (PD) and various forms of tremor or dystonia, these therapies are not yet available for many other brain diseases.

Brain network dynamics and function

In the brain, approximately 86 billion nerve cells interact spatially and temporally to create a highly complex dynamic network whose exact functioning remains one of the great mysteries of brain research. One research focus of the TRR 295 ReTune is to understand the mechanisms and function of dynamic neuronal networks in health and disease in order to retune altered networks by invasive or non-invasive brain stimulation. The aim is to develop innovative neuromodulation systems that respond to specific demands, precisely target individual symptom cycles, and are activated only when disease symptoms occur.

Collaborative Research Centre TRR 295 ReTune

The Collaborative Research Centre TRR 295 ReTune consists of an interdisciplinary team of physicians, neuroscientists, and basic researchers from the Charité – Universitätsmedizin Berlin, Julius-Maximilians-Universität Würzburg, and seven other internationally renowned institutions in Düsseldorf, Potsdam, Leipzig, Rostock, Berlin, Würzburg, and Jerusalem. This multidisciplinary consortium is collaborating on various research projects, each addressing specific aspects of motor network disorders. The joint project is being funded with ten million euros by the German Research Foundation (DFG) for an initial period of four years starting in 2020.

Learn more about our TRR 295

“Our vision is to develop network-specific, yet minimally invasive neuromodulation methods for clinical practice to set new standards in the treatment of complex neurological movement disorders.”

Prof. Dr. Andrea Kühn, spokesperson of the TRR 295 ReTune and Head of Movement Disorders and Neuromodulation Unit at the Department of Neurology with Experimental Neurology, Charité – Universitätsmedizin Berlin.

News & Events

DGKN Congress for Clinical Neuroscience 2024

DGKN Congress for Clinical Neuroscience 2024

Mar 6-9, 2024 | Frankfurt

On the way to personalized medicine
ReTune Paper of the Month 12/2023

ReTune Paper of the Month 12/2023

Dec 30, 2023

Busch & Kaplan et al. 2023 Mov Disord.
ReTune Paper of the Month 11/2023

ReTune Paper of the Month 11/2023

Nov 30, 2023

McFleder et al. 2023 Nat Commun.
Logo of DGN Congress 2023

TRR 295 ReTune at the DGN Congress 2023

Nov 8-11, 2023 | Berlin

TRR 295 ReTune at the MDS International Congress
ReTune Paper of the Month 10/2023

ReTune Paper of the Month 10/2023

Oct 30, 2023

Binder & Lange et al. 2023 Brain Stimul.
Group picture of the Hackathon Event 2023

ReTune Hackathon 2023

October 23-25, 2023 | Bad Belzig

The annual ReTune Hackathon is an intensive and collaborative event, to address a spectrum of scientific coding problems.

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Publications

Brain-to-gut trafficking of alpha-Synuclein by CD11c+ cells in a mouse model of Parkinson’s disease.

McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, Karl AK, Pagenstecher A, Vogel J, Beilhack A, Koprich JB, Brotchie JM, Saliba AE, Volkmann J, Ip CW.

One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics.
Published: Nov 2023

Optimization of data pre-processing methods for time-series classification of electroencephalography data.

Anders C, Curio G, Arnrich B, Waterstraat G.

Here, the influence of spatial filter optimization methods and non-linear data transformation on time-series classification performance is analyzed by the example of high-frequency somatosensory evoked responses.
Published: Nov 2023

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

Neumann WJ, Steiner LA, Milosevic L

 

In this Update we aim to produce an integrative account of complementary instead of mutually exclusive neurophysiological effects to derive a generalizable concept of the mechanisms of deep brain stimulation.
Published: Nov 2023

Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Ayon-Olivas M, Wolf D, Andreska T, Granado N, Lüningschrör P, Ip CW, Moratalla R, Sendtner M.

In this study, we showed that the activation of DRD2 in cultured striatal indirect pathway spiny projection neurons (iSPNs) and cholinergic interneurons causes the retraction of TrkB from the plasma membrane. This provides an explanation for the opposing synaptic plasticity changes observed upon DRD1 or DRD2 stimulation.
Published: Oct 2023

Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson’s Disease.

Busch JL, Kaplan J, Bahners BH, Roediger J, Faust K, Schneider GH, Florin E, Schnitzler A, Krause P, Kühn AA.

Using novel sensing-enabled neurostimulators, we investigated local field potentials (LFPs) and their modulation by DBS to assess whether electrophysiological biomarkers may facilitate clinical programming in chronically implanted patients.
Published: Oct 2023

Prediction of Stroke Outcome in Mice Based on Noninvasive MRI and Behavioral Testing.

Knab F, Koch SP, Major S, Farr TD, Mueller S, Euskirchen P, Eggers M, Kuffner MTC, Walter J, Berchtold D, Knauss S, Dreier JP, Meisel A, Endres M, Dirnagl U, Wenger N, Hoffmann CJ, Boehm-Sturm P*, Harms C*.

Systematic analysis of stroke outcome predictors in mice is lacking. We developed a tool to predict late pellet reaching performance based on early stroke localization in a diverse cohort of 215 mice.
Published: Sep 2023

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