We will characterize the oscillatory network signatures of two clinically-similar hyperkinetic movement disorders, dystonia and levodopa-induced dyskinesia. We assume that in both conditions, there are similar symptom-specific network dysfunctions locally and on the network level.
The results obtained in this project from parallel local field potential recordings of the pallidum and striatum, as well as electrocorticography and magnetoencephalography recordings, will increase the understanding of dynamic basal ganglia-cortex interactions, help to identify physiomarkers of hyperkinetic states, and guide the development of adaptive deep brain stimulation algorithms specifically targeting hyperkinesia.
Team
Publications
Neuroimaging-based analysis of DBS outcomes in pediatric dystonia: Insights from the GEPESTIM registry.
- Prof. Andrea Kühn
- Juanli Zhang
- Prof. Alfons Schnitzler
Insights and opportunities for deep brain stimulation as a brain circuit intervention.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
Christmas-Related Reduction in Beta Activity in Parkinson’s Disease
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Johannes Busch
- Varvara Mathiopoulou
- Dr. Gerd-Helge Schneider
- Dr. Andreas Horn
- Prof. Andrea Kühn
- Prof. Julian Neumann
Pallidal Beta Activity Is Linked to Stimulation-Induced Slowness in Dystonia.
- Dr. Roxanne Lofredi
- Dr. Gerd-Helge Schneider
- Dr. Lucia Feldmann
- Prof. Andrea Kühn
Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients.
- Dr. Roxanne Lofredi
- Dr. Gerd-Helge Schneider
- Prof. Julian Neumann
- Prof. Andrea Kühn
Interrater reliability of deep brain stimulation electrode localizations.
- Dr. Roxanne Lofredi
- Prof. Andrea Kühn
- Dr. Andreas Horn
Spectral and spatial distribution of subthalamic beta peak activity in Parkinson’s disease patients.
- Dr. Natasha Darcy
- Dr. Roxanne Lofredi
- Prof. Julian Neumann
- Dr. Gerd-Helge Schneider
- Prof. Andrea Kühn
A translational perspective on pathophysiological changes of oscillatory activity in dystonia and parkinsonism.
- Dr. Lisa Rauschenberger
- Prof. Jens Volkmann
- Prof. Andrea Kühn
- Prof. Chi Wang Ip
- Dr. Roxanne Lofredi
Long-term effects of pallidal deep brain stimulation in tardive dystonia: a follow-up of 5–14 years.
- Dr. Gerd-Helge Schneider
- Prof. Andrea Kühn
Subthalamic stimulation impairs stopping of ongoing movements.
- Dr. Roxanne Lofredi
- Prof. Julian Neumann
- Prof. Andrea Kühn
- Dr. Gerd-Helge Schneider