Deep brain stimulation (DBS) is an effective treatment for idiopathic dystonia but highly variable in patients with acquired dystonia due to brain lesions. Moreover, some patients may not receive optimal clinical benefits due to the large parameter space and delayed clinical effects of DBS programming.

Herein, we will combine advanced neurophysiological and imaging approaches to systematically evaluate the predictive capacity of neurobiological hallmarks in children and adults with dystonia in order to ascertain precise symptom-specific functional network properties of hyperkinesia. The ultimate goal is to guide DBS strategies to optimize therapeutic outcomes in hyperkinesia.