Parkinson’s disease (PD) is characterized by a loss of dopaminergic innervation to the basal ganglia. One of the cardinal symptoms of PD is akinesia, the delay or failure to initiate movement.
With the present project we will address the central aim to characterize the function of cortex – basal ganglia communication during movement initiation and its impairment in PD patients. It builds on a behavioural task in combination with experiments using whole-brain connectomics and invasive closed loop neuromodulation.
The proposed project leverages deep brain stimulation as a causal brain network intervention and promises insight into the fundamental circuit computations underlying cortex – basal ganglia coupling for movement initiation, action selection and the pathophysiology of Parkinson’s disease.
Team
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Prof. Julian Neumann
Charité – Universitätsmedizin Berlin
Steering Committee and Equal Opportunity Committee Member, Project Leader
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PD Dr. Katharina Faust
Charité – Universitätsmedizin Berlin
Project Leader
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Prof. John-Dylan Haynes
Charité – Universitätsmedizin Berlin
Project Leader
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Richard Köhler
Charité – Universitätsmedizin Berlin
Postdoc
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Hakimeh Pourakbari
Charité – Universitätsmedizin Berlin
PhD Student
Publications
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
- Prof. Julian Neumann
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance.
- Prof. Andrea Kühn
- Prof. Hagai Bergman
- Prof. Julian Neumann
Insights and opportunities for deep brain stimulation as a brain circuit intervention.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
Christmas-Related Reduction in Beta Activity in Parkinson’s Disease
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Johannes Busch
- Varvara Mathiopoulou
- Dr. Gerd-Helge Schneider
- Dr. Andreas Horn
- Prof. Andrea Kühn
- Prof. Julian Neumann
Movement Decoding Using Spatio-Spectral Features of Cortical and Subcortical Local Field Potentials
- Prof. Andrea Kühn
- Dr. Vadim Nikulin
- Prof. Julian Neumann
A practical guide to invasive neurophysiology in patients with deep brain stimulation.
- Prof. Julian Neumann
- Richard Köhler
- Prof. Andrea Kühn
Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease.
- Dr. Ningfei Li
- Dr. Andreas Horn
- Prof. Julian Neumann
Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation.
- Richard Köhler
- Prof. Stefan Haufe
- Prof. Julian Neumann
Journal Article: Discovering the hidden life of the basal ganglia.
- Dr. Andreas Horn