Area B

B03 | Decoding therapy-related inhibition / disinhibition signaling through M1 ECoG and subthalamic LFP real-time classification in patients with Parkinson’s disease

This project aims to disentangle the pathophysiological role of oscillatory cortex-basal ganglia dynamics in the initiation, suppression, and cancellation of voluntary movements in Parkinson’s disease by uniting complementary expertise in invasive neurophysiology for movement disorders and multivariate decoding of volitional behavior.

The project will establish a real-time, clinical brain computer interface with invasive multielectrode recordings of neural population activity – a prerequisite for the interrogation of task- and activity-dependent neuromodulation approaches in the TRR.