The exact neurophysiological mechanisms of subthalamic (STN) deep brain stimulation (DBS) in Parkinson’s disease are still not well understood. Therefore, neuronal activity will be non-invasively recorded during different stimulation settings using magnetoencephalography. The effects of stimulation conditions on a) evoked cortical responses, b) induced local cortical oscillatory activity, c) induced oscillatory network activity, and d) oscillatory resting state networks will be quantified and related to clinical symptoms.
With this project, we anticipate advancing our understanding of the mechanisms of STN-DBS. Such knowledge will be instrumental to enhance the development of optimized DBS programming algorithms and adaptive neurostimulation.