In the first funding period, we identified cortical responses evoked by single-pulse stimulation of the subthalamic nucleus (STN). We established a relationship between these responses and clinical outcome, which could be utilized to determine optimal STN deep brain stimulation (DBS).
Within the new funding period, this knowledge will be used to characterize the temporal dynamics of the basal-ganglia-thalamo-cortical activity to better understand the modulatory effects of STN-DBS on this network. Based on these insights, adaptive stimulation protocols will be developed to modulate abnormal dynamics and provide more efficient STN-DBS.
Team
-
Prof. Esther Florin
Heinrich-Heine-Universität Düsseldorf
Steering Committee Member, Project Leader
-
Prof. Alfons Schnitzler
Heinrich-Heine-Universität Düsseldorf
Project Leader
-
Dr. Bahne Bahners
Heinrich-Heine-Universität Düsseldorf
Postdoc
-
Dr. Rachel Spooner
Heinrich-Heine-Universität Düsseldorf
Project Leader
Publications
Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson’s Disease.
- Prof. Esther Florin
- Prof. Alfons Schnitzler
- Dr. Bahne Bahners
- Dr. Gerd-Helge Schneider
- Jonathan Kaplan
- Johannes Busch
- Prof. Andrea Kühn
A First Methodological Development and Validation of ReTap: An Open-Source UPDRS Finger Tapping Assessment Tool Based on Accelerometer-Data
- Dr. Rachel Spooner
- Varvara Mathiopoulou
- Dr. Lucia Feldmann
- Johannes Busch
- Dr. Bahne Bahners
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Andrea Kühn
DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson’s disease.
- Dr. Rachel Spooner
- Dr. Bahne Bahners
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson’s disease.
- Dr. Bahne Bahners
- Dr. Rachel Spooner
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Alterations of resting-state networks of Parkinson‘s disease patients after subthalamic DBS surgery.
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Cortical network formation based on subthalamic beta bursts in Parkinson’s disease.
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation.
- Dr. Bahne Bahners
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
- Prof. Alfons Schnitzler
- Dr. Vadim Nikulin
- Prof. Esther Florin
Neuronal oscillations predict deep brain stimulation outcome in Parkinson’s disease.
- Prof. Esther Florin
- Prof. Alfons Schnitzler
Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Prof. Julian Neumann
- Dr. Bahne Bahners
- Prof. Esther Florin
- Prof. Alfons Schnitzler
- Dr. Gerd-Helge Schneider
- Prof. Andrea Kühn
Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations.
- Moritz Gerster
- Dr. Gunnar Waterstraat
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Gabriel Curio
- Dr. Vadim Nikulin
