Area C

C04 | Advancing neurostimulation to symptom-related individual adaptive stimulation: theoretical models and clinical application

In this project, we will develop an innovative protocol for adaptive stimulation in Parkinson’s disease patients. Adaptive stimulation will be based on simultaneous local field potential recordings from the basal ganglia, as well as cortical brain signals (electrocorticography).

We will use these to identify new biomarkers that will allow us to individually adapt deep brain stimulation to various symptoms and physiological activity, and include theoretical stimulation models to optimize control variables.

By the end of the funding period, we aim to provide an optimized adaptive stimulation protocol suitable for long-term recordings, which can be applied in a clinical study in the second funding period