In this project, we will develop an innovative protocol for adaptive stimulation in Parkinson’s disease patients. Adaptive stimulation will be based on simultaneous local field potential recordings from the basal ganglia, as well as cortical brain signals (electrocorticography).
We will use these to identify new biomarkers that will allow us to individually adapt deep brain stimulation to various symptoms and physiological activity, and include theoretical stimulation models to optimize control variables.
By the end of the funding period, we aim to provide an optimized adaptive stimulation protocol suitable for long-term recordings, which can be applied in a clinical study in the second funding period
Team
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Prof. Andrea Kühn
Charité – Universitätsmedizin Berlin
Spokesperson, Steering Committee Member, Project Leader
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Dr. Gerd-Helge Schneider
Charité – Universitätsmedizin Berlin
Project Leader
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Prof. Michael Rosenblum
Universität Potsdam
Project Leader
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Dr. Lucia Feldmann
Charité – Universitätsmedizin Berlin
Postdoc
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Erik Mau
Universität Potsdam
PhD Student
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Johannes Busch
Charité – Universitätsmedizin Berlin
Postdoc
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Jonathan Kaplan
Charité – Universitätsmedizin Berlin
MD Student
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Varvara Mathiopoulou
Charité – Universitätsmedizin Berlin
PhD Student