The exact neurophysiological mechanisms of subthalamic (STN) deep brain stimulation (DBS) in Parkinson’s disease are still not well understood. Therefore, neuronal activity will be non-invasively recorded during different stimulation settings using magnetoencephalography. The effects of stimulation conditions on a) evoked cortical responses, b) induced local cortical oscillatory activity, c) induced oscillatory network activity, and d) oscillatory resting state networks will be quantified and related to clinical symptoms.
With this project, we anticipate advancing our understanding of the mechanisms of STN-DBS. Such knowledge will be instrumental to enhance the development of optimized DBS programming algorithms and adaptive neurostimulation.
Team
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Prof. Esther Florin
Heinrich-Heine-Universität Düsseldorf
Steering Committee and Early Career Scientist Committee Member, Project Leader
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Prof. Alfons Schnitzler
Heinrich-Heine-Universität Düsseldorf
Project Leader
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Dr. Bahne Bahners
Heinrich-Heine-Universität Düsseldorf
Postdoc
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Dr. Rachel Spooner
Heinrich-Heine-Universität Düsseldorf
Postdoc
Publications
Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson’s Disease.
- Prof. Esther Florin
- Prof. Alfons Schnitzler
- Dr. Bahne Bahners
- Dr. Gerd-Helge Schneider
- Jonathan Kaplan
- Johannes Busch
- Prof. Andrea Kühn
A First Methodological Development and Validation of ReTap: An Open-Source UPDRS Finger Tapping Assessment Tool Based on Accelerometer-Data
- Dr. Rachel Spooner
- Varvara Mathiopoulou
- Dr. Lucia Feldmann
- Johannes Busch
- Dr. Bahne Bahners
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Andrea Kühn
DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson’s disease.
- Dr. Rachel Spooner
- Dr. Bahne Bahners
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson’s disease.
- Dr. Bahne Bahners
- Dr. Rachel Spooner
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Alterations of resting-state networks of Parkinson‘s disease patients after subthalamic DBS surgery.
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Cortical network formation based on subthalamic beta bursts in Parkinson’s disease.
- Prof. Alfons Schnitzler
- Prof. Esther Florin
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation.
- Dr. Bahne Bahners
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
- Prof. Alfons Schnitzler
- Dr. Vadim Nikulin
- Prof. Esther Florin
Neuronal oscillations predict deep brain stimulation outcome in Parkinson’s disease.
- Prof. Esther Florin
- Prof. Alfons Schnitzler
Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Prof. Julian Neumann
- Dr. Bahne Bahners
- Prof. Esther Florin
- Prof. Alfons Schnitzler
- Dr. Gerd-Helge Schneider
- Prof. Andrea Kühn
Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations.
- Moritz Gerster
- Dr. Gunnar Waterstraat
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Gabriel Curio
- Dr. Vadim Nikulin