In this project, we will assemble a comprehensive database of the functional connectivity within and between nuclei of the basal ganglia of non-human primates throughout the sleep-wake cycle, before and following MPTP intoxication and development of Parkinson’s disease. This information will enable us to design frequency- and phase-specific closed-loop deep brain stimulation therapy that adapts to the circadian rhythm and thereby improves the quality of life of upcoming generations of Parkinson’s disease patients.
Team
Publications
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance.
- Prof. Andrea Kühn
- Prof. Hagai Bergman
- Prof. Julian Neumann
Dichotomous activity and function of neurons with low- and high-frequency discharge in the external globus pallidus of non-human primates.
- Prof. Hagai Bergman
Entrainment to sleep spindles reflects dissociable patterns of connectivity between cortex and basal ganglia
- Prof. Hagai Bergman
Spontaneous pauses in firing of external pallidum neurons are associated with exploratory behavior
- Prof. Hagai Bergman
Etiologies of insomnia in Parkinson’s disease – Lessons from human studies and animal models.
- Prof. Andrea Kühn
- Prof. Hagai Bergman
- Dr. Lucia Feldmann
Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.
- Prof. Hagai Bergman
Deep Brain Stimulation Can Differentiate Subregions of the Human Subthalamic Nucleus Area by EEG Biomarkers.
- Prof. Hagai Bergman
Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity.
- Dr. Jing Guang
- Prof. Hagai Bergman
