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TRR 295

Retuning dynamic motor network disorders using neuromodulation

Research insights and latest results of the Transregional Collaborative Research Center TRR 295 ReTune, funded by the German Research Foundation (DFG), to improve the therapy of brain disorders.

Standard of care

Development of innovative neuromodulation therapies

A lot of neurological diseases are associated with movement disorders. Neuromodulation that applies therapeutic electric currents or magnetic fields to the brain has demonstrated the ability to restore motor deficits in movement disorder patients. Deep brain stimulation (DBS) is considered a standard and well-accepted treatment option for Parkinson´s disease (PD) and various forms of tremor or dystonia. However, these therapies cannot yet be applied to many other brain diseases.

Brain network dynamics and function

In the brain, around 86 billion nerve cells work together spatially and temporally in a highly complex dynamic network. How this works is one of the greatest mysteries of brain research. One research focus of TRR 295 ReTune is to understand the mechanisms and function of dynamic neuronal networks in health and disease in order to retune altered networks by invasive or non-invasive brain stimulation. The aim is to develop innovative, demand-controlled neuromodulation systems that target individual symptom circuits with high precision and only become active when disease symptoms occur.

Gebäude der Charité in Blau

© katatonia –

Collaborative Research Centre TRR 295 ReTune

The Collaborative Research Centre TRR 295 ReTune brings together an interdisciplinary team of physicians, neuroscientists and basic researchers from the Charité – Universitätsmedizin Berlin, Julius-Maximilians-Universität Würzburg and seven other internationally renowned universities from Düsseldorf, Potsdam, Leipzig, Rostock, Berlin, Würzburg and Jerusalem. The multidisciplinary consortium is collaborating on various research projects, each approching specific aspects of motor network disorders. The joint project has been funded by the German Research Foundation (DFG) for an initial period of four years, starting in 2020, with ten million euros.

Learn more about our TRR 295

„Our vision is to develop network-specific but minimally invasive neuromodulation methods for clinical practice to set new standards in the treatment of complex neurological movement disorders.“

Prof. Dr. Andrea Kühn, Spokesperson of the TRR 295 ReTune and Head of Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin.

News & Events

ReTune Paper of the Month 04/2023

ReTune Paper of the Month 04/2023

Apr 30, 2023

Rauschenberger et al. 2023 Neurobiol. Dis.
ReTune Paper of the Month 03/2023

ReTune Paper of the Month 03/2023

Mar 30, 2023

Spooner et al. 2023 NPJ Parkinson's Disease.
ReTune Symposium 2023

ReTune Symposium 2023

Feb 8-10, 2023 | Landgut Stober

Keynote Lecture: Prof. Aryn Gittis
ReTune Paper of the Month 02/2023

ReTune Paper of the Month 02/2023

Feb 20, 2023

Lofredi et al. 2023 NPJ Parkinson's Disease.
ReTune Paper of the Month 01/2023

ReTune Paper of the Month 01/2023

Jan 20, 2023

Badr & McFleder et al. 2022 J Neuroinflammation.

All News & Events


Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts

Del Vecchio Del Vecchio J, Hanafi I, Pozzi NG, Capetian P, Isaias IU, Haufe S, Palmisano C.

Head tremor, a low-frequency involuntary rhythmic movement typical of cervical dystonia, may cause movement artifacts in LFP signals, compromising the reliability of low-frequency oscillations as biomarkers for adaptive neurostimulation.
Published: Apr 2023

The return of the lesion for localization and therapy.

Joutsa J, Lipsman N, Horn A, Cosgrove GR, Fox MD.
Recent advances have improved our ability to localize lesion-induced symptoms, including localization to brain circuits rather than individual brain regions.
Published: Apr 2023

Peripheral nerve injury elicits microstructural and neurochemical changes in the striatum and substantia nigra of a DYT-TOR1A mouse model with dystonia-like movements.

Rauschenberger L, Krenig EM, Stengl A, Knorr S, Harder TH, Steeg F, Friedrich MU, Grundmann-Hauser K, Volkmann J, Ip CW.

To analyze whether recovery from a peripheral nerve injury can trigger a dystonic phenotype in asymptomatic hΔGAG3 mice, which overexpress human mutated torsinA, a sciatic nerve crush was applied.
Published: Apr 2023

Distinct phenotypes of stimulation-induced dysarthria represent different cortical networks in STN-DBS

Lange F, Eldebakey H, Hilgenberg A, Weigl B, Eckert M, DeSunda A, Neugebauer H, Peach R, Roothans J, Volkmann J, Reich MM.
In this study, we [...] test the real-life application of the proposed clustering [of phenotypes of dysarthria, that] has been proposed to tackle stimulation-induced speech problems.
Published: Apr 2023

Deep learning-enabled segmentation of ambiguous bioimages with deepflash2.

Griebel M, Segebarth D, Stein N, Schukraft N, Tovote P, Blum R, Flath CM.

Here we introduce deepflash2, a deep learning-enabled segmentation tool for bioimage analysis. The tool addresses typical challenges that may arise during the training, evaluation, and application of deep learning models on ambiguous data.
Published: Mar 2023

Machine Learning in Tremor Analysis: Critique and Directions.

De A, Bhatia KP, Volkmann J, Peach R, Schreglmann SR.
This work summarizes and highlights recent developments in machine-learning (ML) tools for tremor research, with a focus on supervised ML.
Published: Mar 2023

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