TRR 295

Retuning dynamic motor network disorders using neuromodulation


Collaborative Research Centre
TRR 295 ReTune

Our TRR 295 seeks to improve the understanding of the various symptoms of human movement disorders by elucidating symptom-specific neural activity and developing specific treatment strategies for network modulation in common and clinically-relevant neurological diseases. We hypothesize that neuromodulation is a promising tool that can modify network activity and restore motor function by eliminating pathological network activity, augmenting normal interareal communication, or activating compensatory circuits.

News & Events

Translational Bioimaging RVZ Symposium

Translational Bioimaging RVZ Symposium

Sep 18-20, 2022 | Würzburg

The Translational Bioimaging Symposium will be hosted by the Rudolf Virchow Center in Würzburg, Germany. Supported by ReTune.
Open Position: Research Assistant (m/f/d) in Rostock

Open Position: Research Assistant (m/f/d) in Rostock

Join ReTune to work on deep brain stimulation modeling with OSS-DBS, leadDBS and similar topics. Prof. Ursula van Rienen is looking for a Postdoc. Collaborations with Andrea Kühn, Andreas Horn, Petra Ritter, Julian Neumann anticipated!
Experimental Neurology Special Issue: Neuromodulation

Experimental Neurology Special Issue: Neuromodulation

Edited by Andrea A. Kühn & Jens Volkmann.

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Non-zero mean alpha oscillations revealed with computational model and empirical data

Alina A Studenova, Arno Villringer, Vadim Nikulin

Ongoing oscillations and evoked responses are two main types of neuronal activity obtained with diverse electrophysiological recordings (EEG/MEG/iEEG/LFP). Although typically studied separately, they might in fact be closely related. One possibility to unite them is to demonstrate that neuronal oscillations have non-zero mean which predicts that stimulus- or task-triggered amplitude modulation of oscillations can contribute to the generation of evoked responses. ...
Published: 2022 Jul

No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease

Alexandra C Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T Barbe, Esther Florin, Elke Kalbe

Parkinson's disease (PD) has been associated with a tendency towards more risky decisions. However, the commonly used paradigms typically neglect the social context. Here, we investigated social decision-making and self-estimation in a competitive experimental task. ...
Published: 2022 Jan
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Bahne H. BahnersGunnar WaterstraatSilja KannenbergGabriel CurioAlfons SchnitzlerVadim NikulinEsther Florin

The subthalamic nucleus (STN) receives input from various cortical areas via hyperdirect pathway (HDP) which bypasses the basal-ganglia loop. Recently, the HDP has gained increasing interest, because of its relevance for STN deep brain stimulation (DBS). To understand the HDP's role cortical responses evoked by STN-DBS have been investigated. ...
Published: 2022 Mar

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