Research insights and latest results of the Transregional Collaborative Research Center TRR 295 ReTune, funded by the German Research Foundation (DFG), to improve the therapy of brain disorders.
A lot of neurological diseases are associated with movement disorders. Neuromodulation that applies therapeutic electric currents or magnetic fields to the brain has demonstrated the ability to restore motor deficits in movement disorder patients. Deep brain stimulation (DBS) is considered a standard and well-accepted treatment option for Parkinson´s disease (PD) and various forms of tremor or dystonia. However, these therapies cannot yet be applied to many other brain diseases.
In the brain, around 86 billion nerve cells work together spatially and temporally in a highly complex dynamic network. How this works is one of the greatest mysteries of brain research. One research focus of TRR 295 ReTune is to understand the mechanisms and function of dynamic neuronal networks in health and disease in order to retune altered networks by invasive or non-invasive brain stimulation. The aim is to develop innovative, demand-controlled neuromodulation systems that target individual symptom circuits with high precision and only become active when disease symptoms occur.
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The Collaborative Research Centre TRR 295 ReTune brings together an interdisciplinary team of physicians, neuroscientists and basic researchers from the Charité – Universitätsmedizin Berlin, Julius-Maximilians-Universität Würzburg and seven other internationally renowned universities from Düsseldorf, Potsdam, Leipzig, Rostock, Berlin, Würzburg and Jerusalem. The multidisciplinary consortium is collaborating on various research projects, each approching specific aspects of motor network disorders. The joint project has been funded by the German Research Foundation (DFG) for an initial period of four years, starting in 2020, with ten million euros.
Nov 1, 2022 | Düsseldorf
Del Vecchio Del Vecchio J, Hanafi I, Pozzi NG, Capetian P, Isaias IU, Haufe S, Palmisano C.
Rauschenberger L, Krenig EM, Stengl A, Knorr S, Harder TH, Steeg F, Friedrich MU, Grundmann-Hauser K, Volkmann J, Ip CW.
Griebel M, Segebarth D, Stein N, Schukraft N, Tovote P, Blum R, Flath CM.
