Recent research highlights the intricate interactions between cognitive, limbic, and motor brain networks that are critical for complex tasks such as walking. Despite the effectiveness of deep brain stimulation (DBS) in improving motor symptoms in Parkinson’s disease (PD), restoring differentiated motor skills, notably gait, remains a challenge.

Normative connectomics studies in large patient cohorts will be used to uncover overlapping networks in ischemic stroke patients and in PD patients undergoing DBS to decipher potential cross-domain interactions between brain networks. The modulation of these cross-domain interactions will be investigated in a pilot interventional DBS study to pave the way for a more personalized treatment approach.