Recent research highlights the intricate interactions between cognitive, limbic, and motor brain networks that are critical for complex tasks such as walking. Despite the effectiveness of deep brain stimulation (DBS) in improving motor symptoms in Parkinson’s disease (PD), restoring differentiated motor skills, notably gait, remains a challenge.
Normative connectomics studies in large patient cohorts will be used to uncover overlapping networks in ischemic stroke patients and in PD patients undergoing DBS to decipher potential cross-domain interactions between brain networks. The modulation of these cross-domain interactions will be investigated in a pilot interventional DBS study to pave the way for a more personalized treatment approach.
Team
-
Anna Kufner, MD/PhD
Charité – Universitätsmedizin Berlin
Project Leader
-
Prof. Matthias Endres
Charité – Universitätsmedizin Berlin
Steering Committee Member, Project Leader
-
Prof. Martin Reich
UniversitätsÂklinikum WĂĽrzburg
Project Leader
-
Yunyou Tang
Charité – Universitätsmedizin Berlin
PhD Student
Publications
Cardiac optogenetics: regulating brain states via the heart
- Prof. Philip Tovote
Integrated cardio-behavioral responses to threat define defensive states.
Cerebellar contribution to the regulation of defensive states.
- Prof. Philip Tovote
Deep learning-enabled segmentation of ambiguous bioimages with deepflash2.
- Dennis Segebarth
- Prof. Philip Tovote
- PD Dr. Robert Blum
Rodent models for gait network disorders in Parkinson’s disease – a translational perspective.
- Dr. Nikolaus Wenger
- Elisa Garulli
- Burçe Kabaoğlu
- Dr. Michael Schuhmann
- Prof. Chi Wang Ip
- Prof. Christoph Harms
- Prof. Matthias Endres
- Prof. Ioannis Isaias
- Prof. Philip Tovote
- PD Dr. Robert Blum
Circuits for State-Dependent Modulation of Locomotion.
- Dr. Alejandro PernĂa Andrade
- Dr. Nikolaus Wenger
- Prof. Philip Tovote
The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network.
- Dr. Susanne Knorr
- Dr. Lisa Harder-Rauschenberger
- Dr. PhD. Robert Peach
- Prof. Philip Tovote
- Prof. Jens Volkmann
- Prof. Chi Wang Ip
Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson’s disease in rodent models
- Dr. Yangfan Peng
- Nina Schöneberg
- Prof. Jörg Geiger
- Prof. Philip Tovote
Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning
- Dr. Thomas Andreska
- PD Dr. Robert Blum
- Prof. Philip Tovote
- Prof. Michael Sendtner
