This project pursues three major aims: 1) to characterize the neuroarchitecture and function of the dopaminergic substantia nigra pars compacta (SNc) and noradrenergic locus coeruleus (LC) projections onto periaqueductal gray (PAG) defense circuits; 2) to validate a cell-type and projection-specific viral model of synucleinopathy within SNc/LC/PAG circuits, and to understand its effects on motor- and anxiety-related behavior; 3) to probe the effects of acute and chronic optogenetic subthalamic nucleus stimulation on the characterized function of SNc/LC/PAG circuitry.
Team
Publications
Cardiac optogenetics: regulating brain states via the heart
- Prof. Philip Tovote
Cerebellar contribution to the regulation of defensive states.
- Prof. Philip Tovote
Deep learning-enabled segmentation of ambiguous bioimages with deepflash2.
- Dennis Segebarth
- Prof. Philip Tovote
- PD Dr. Robert Blum
Integrated cardio-behavioral responses to threat define defensive states
- Dennis Segebarth
- Prof. Philip Tovote
Rodent models for gait network disorders in Parkinson’s disease – a translational perspective.
- Dr. Nikolaus Wenger
- Elisa Garulli
- Burçe Kabaoğlu
- Dr. Michael Schuhmann
- Prof. Chi Wang Ip
- Prof. Christoph Harms
- Prof. Matthias Endres
- Prof. Ioannis Isaias
- Prof. Philip Tovote
- PD Dr. Robert Blum
Circuits for State-Dependent Modulation of Locomotion.
- Dr. Alejandro Pernía Andrade
- Dr. Nikolaus Wenger
- Prof. Philip Tovote
The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network.
- Dr. Susanne Knorr
- Dr. Lisa Rauschenberger
- Prof. Philip Tovote
- Prof. Jens Volkmann
- Prof. Chi Wang Ip
Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson’s disease in rodent models
- Dr. Yangfan Peng
- Nina Schöneberg
- Prof. Jörg Geiger
- Prof. Philip Tovote
Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning
- Dr. Thomas Andreska
- PD Dr. Robert Blum
- Prof. Philip Tovote
- Prof. Michael Sendtner
