This project will quantify local and global neuronal dynamics using measures reflecting excitability and complexity (e.g., 1/f-spectrum, long-range temporal correlations), which will be related to linear and non-linear cross-frequency interactions between remote yet connected structures in cortex-basal ganglia circuitry.
We will investigate how DBS-evoked, cortical high-frequency activity relates to therapeutic effects of DBS due to “hyperdirect” antidromic cortex stimulation. Computational modeling will analyze how antidromic cortical stimulation depends on the state of cortical neurons, reflected in the phase and amplitude of ongoing oscillations.
Team
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Dr. Vadim Nikulin
Max-Planck-Institut für Kognitions- und Neurowissenschaften
Project Leader
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Prof. Gabriel Curio
Charité – Universitätsmedizin Berlin
Steering Committee Member, Project Leader
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Dr. Gunnar Waterstraat
Charité – Universitätsmedizin Berlin
Postdoc
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Moritz Gerster
Max-Planck-Institut für Kognitions- und Neurowissenschaften
PhD Student
Publications
Non-zero mean alpha oscillations revealed with computational model and empirical data
- Dr. Vadim Nikulin
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation
- Dr. Bahne Bahners
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
- Prof. Alfons Schnitzler
- Dr. Vadim Nikulin
- Prof. Esther Florin
Neuronal biomarkers of Parkinson’s disease are present in healthy aging
- Juanli Zhang
- Dr. Vadim Nikulin
Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio