This project will quantify local and global neuronal dynamics using measures reflecting excitability and complexity (e.g., 1/f-spectrum, long-range temporal correlations), which will be related to linear and non-linear cross-frequency interactions between remote yet connected structures in cortex-basal ganglia circuitry.

We will investigate how DBS-evoked, cortical high-frequency activity relates to therapeutic effects of DBS due to “hyperdirect” antidromic cortex stimulation. Computational modeling will analyze how antidromic cortical stimulation depends on the state of cortical neurons, reflected in the phase and amplitude of ongoing oscillations.