This project aims to disentangle the pathophysiological role of oscillatory cortex-basal ganglia dynamics in the initiation, suppression, and cancellation of voluntary movements in Parkinson’s disease by uniting complementary expertise in invasive neurophysiology for movement disorders and multivariate decoding of volitional behavior.
The project will establish a real-time, clinical brain computer interface with invasive multielectrode recordings of neural population activity – a prerequisite for the interrogation of task- and activity-dependent neuromodulation approaches in the TRR.
Team
Publications
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
- Prof. Julian Neumann
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance.
- Prof. Andrea Kühn
- Prof. Hagai Bergman
- Prof. Julian Neumann
Insights and opportunities for deep brain stimulation as a brain circuit intervention.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
Christmas-Related Reduction in Beta Activity in Parkinson’s Disease
- Dr. Lucia Feldmann
- Dr. Roxanne Lofredi
- Johannes Busch
- Varvara Mathiopoulou
- Dr. Gerd-Helge Schneider
- Dr. Andreas Horn
- Prof. Andrea Kühn
- Prof. Julian Neumann
Movement Decoding Using Spatio-Spectral Features of Cortical and Subcortical Local Field Potentials
- Prof. Andrea Kühn
- Dr. Vadim Nikulin
- Prof. Julian Neumann
A practical guide to invasive neurophysiology in patients with deep brain stimulation.
- Prof. Julian Neumann
- Richard Köhler
- Prof. Andrea Kühn
Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region.
- Prof. Julian Neumann
- Dr. Andreas Horn
- Prof. Andrea Kühn
Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease.
- Dr. Ningfei Li
- Dr. Andreas Horn
- Prof. Julian Neumann
Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation.
- Richard Köhler
- Prof. Stefan Haufe
- Prof. Julian Neumann
Journal Article: Discovering the hidden life of the basal ganglia.
- Dr. Andreas Horn