This project will quantify local and global neuronal dynamics using measures reflecting excitability and complexity (e.g., 1/f-spectrum, long-range temporal correlations), which will be related to linear and non-linear cross-frequency interactions between remote yet connected structures in cortex-basal ganglia circuitry.
We will investigate how DBS-evoked, cortical high-frequency activity relates to therapeutic effects of DBS due to “hyperdirect” antidromic cortex stimulation. Computational modeling will analyze how antidromic cortical stimulation depends on the state of cortical neurons, reflected in the phase and amplitude of ongoing oscillations.
Team
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Dr. Vadim Nikulin
Max-Planck-Institut für Kognitions- und Neurowissenschaften
B02 Alumnus Project Leader
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Prof. Gabriel Curio
Charité – Universitätsmedizin Berlin
B02 Alumnus Project Leader & Steering Committee Member
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Dr. Gunnar Waterstraat
Charité – Universitätsmedizin Berlin
A04 Alumnus
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Moritz Gerster
Max-Planck-Institut für Kognitions- und Neurowissenschaften
B02 Alumnus
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Juanli Zhang
Max-Planck-Institut für Kognitions- und Neurowissenschaften
B02 Alumna
Publications
Optimization of data pre-processing methods for time-series classification of electroencephalography data.
- Prof. Gabriel Curio
- Dr. Gunnar Waterstraat
Identifying good practices for detecting inter-regional linear functional connectivity from EEG.
- Franziska Pellegrini
- Dr. Vadim Nikulin
- Prof. Stefan Haufe
Movement Decoding Using Spatio-Spectral Features of Cortical and Subcortical Local Field Potentials
- Prof. Andrea Kühn
- Dr. Vadim Nikulin
- Prof. Julian Neumann
Non-zero mean alpha oscillations revealed with computational model and empirical data
- Dr. Vadim Nikulin
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation.
- Dr. Bahne Bahners
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
- Prof. Alfons Schnitzler
- Dr. Vadim Nikulin
- Prof. Esther Florin
Dopaminergic Modulation of Local Non-oscillatory Activity and Global-Network Properties in Parkinson’s Disease: An EEG Study.
- Juanli Zhang
- Dr. Vadim Nikulin
Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations.
- Moritz Gerster
- Dr. Gunnar Waterstraat
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Gabriel Curio
- Dr. Vadim Nikulin
Neuronal biomarkers of Parkinson’s disease are present in healthy aging
- Juanli Zhang
- Dr. Vadim Nikulin
Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
