This project will quantify local and global neuronal dynamics using measures reflecting excitability and complexity (e.g., 1/f-spectrum, long-range temporal correlations), which will be related to linear and non-linear cross-frequency interactions between remote yet connected structures in cortex-basal ganglia circuitry.
We will investigate how DBS-evoked, cortical high-frequency activity relates to therapeutic effects of DBS due to âhyperdirectâ antidromic cortex stimulation. Computational modeling will analyze how antidromic cortical stimulation depends on the state of cortical neurons, reflected in the phase and amplitude of ongoing oscillations.
Team
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Dr. Vadim Nikulin
Max-Planck-Institut fĂŒr Kognitions- und Neurowissenschaften
Project Leader
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Prof. Gabriel Curio
CharitĂ© â UniversitĂ€tsmedizin Berlin
Steering Committee Member, Project Leader
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Dr. Gunnar Waterstraat
CharitĂ© â UniversitĂ€tsmedizin Berlin
Postdoc
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Moritz Gerster
Max-Planck-Institut fĂŒr Kognitions- und Neurowissenschaften
PhD Student
Publications
Optimization of data pre-processing methods for time-series classification of electroencephalography data.
- Prof. Gabriel Curio
- Dr. Gunnar Waterstraat
Identifying good practices for detecting inter-regional linear functional connectivity from EEG.
- Franziska Pellegrini
- Dr. Vadim Nikulin
- Prof. Stefan Haufe
Movement Decoding Using Spatio-Spectral Features of Cortical and Subcortical Local Field Potentials
- Prof. Andrea KĂŒhn
- Dr. Vadim Nikulin
- Prof. Julian Neumann
Non-zero mean alpha oscillations revealed with computational model and empirical data
- Dr. Vadim Nikulin
Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation.
- Dr. Bahne Bahners
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
- Prof. Alfons Schnitzler
- Dr. Vadim Nikulin
- Prof. Esther Florin
Dopaminergic Modulation of Local Non-oscillatory Activity and Global-Network Properties in Parkinson’s Disease: An EEG Study.
- Juanli Zhang
- Dr. Vadim Nikulin
Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations.
- Moritz Gerster
- Dr. Gunnar Waterstraat
- Prof. Alfons Schnitzler
- Prof. Esther Florin
- Prof. Gabriel Curio
- Dr. Vadim Nikulin
Neuronal biomarkers of Parkinsonâs disease are present in healthy aging
- Juanli Zhang
- Dr. Vadim Nikulin
Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes
- Dr. Gunnar Waterstraat
- Prof. Gabriel Curio
