Gait disorders are common to various neurological conditions afflicting the basal ganglia-cortical network. We want to investigate the potential of deep brain stimulation in the mesencephalic locomotor region (MLR) in two lesional models of gait disorders in rats, affecting either the basal ganglia or cortical level: parkinsonian gait and hemiplegic gait after stroke to the sensorimotor cortex. We aim to identify the connectivity, microcircuitry, and functional relevance of specific cell types in the cuneiform nucleus in the MLR for therapeutic retuning of gait.
Team
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Dr. Michael Schuhmann
Universitätsklinikum Würzburg
Project Leader
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PD Dr. Robert Blum
Universitätsklinikum Würzburg
Project Leader
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Prof. Jens Volkmann
Universitätsklinikum Würzburg
Deputy Spokesperson, Steering Committee Member, Project Leader
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Martina Wilhelm
Universitätsklinikum Würzburg
PhD Student
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Yvonne Hammer
Universitätsklinikum Würzburg
PhD Student
Publications
Deep learning-enabled segmentation of ambiguous bioimages with deepflash2.
- Dennis Segebarth
- Prof. Philip Tovote
- PD Dr. Robert Blum
Deep Brain Stimulation in the Subthalamic Nucleus Can Improve Skilled Forelimb Movements and Retune Dynamics of Striatal Networks in a Rat Stroke Model.
- Dr. Michael Schuhmann
- Prof. Jens Volkmann
Rodent models for gait network disorders in Parkinson’s disease – a translational perspective.
- Dr. Nikolaus Wenger
- Elisa Garulli
- Burçe Kabaoğlu
- Dr. Michael Schuhmann
- Prof. Chi Wang Ip
- Prof. Christoph Harms
- Prof. Matthias Endres
- Prof. Ioannis Isaias
- Prof. Philip Tovote
- PD Dr. Robert Blum
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
- Dr. Thomas Andreska
- Daniel Wolf
- Maurilyn Ayon Olivas
- PD Dr. Robert Blum
- Prof. Jens Volkmann
- Prof. Chi Wang Ip
- Prof. Michael Sendtner
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment.
- Dr. Thomas Andreska
- PD Dr. Robert Blum
- Prof. Michael Sendtner
Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice.
- PD Dr. Robert Blum
- Dr. Susanne Knorr
- Prof. Jens Volkmann
- Prof. Chi Wang Ip
Mesencephalic Electrical Stimulation Reduces Neuroinflammation after Photothrombotic Stroke in Rats by Targeting the Cholinergic Anti-Inflammatory Pathway.
- Dr. Michael Schuhmann
- PD Dr. Robert Blum
- Prof. Jens Volkmann
On the objectivity, reliability, and validity of deep learning enabled bioimage analyses.
- Dennis Segebarth
- PD Dr. Robert Blum
Development of a Fully Implantable Stimulator for Deep Brain Stimulation in Mice.
- Prof. Jens Volkmann
- Prof. Michael Sendtner
Changes of cerebral network activity after invasive stimulation of the mesencephalic locomotor region in a rat stroke model
- Prof. Jens Volkmann
- Dr. Michael Schuhmann
