In the first funding period, we have uncovered two potential mechanisms of spinal neuromodulation for gait restoration: the remote modulation of supraspinal networks with high-frequency cervical stimulation and the local modulation of leg muscles with low-frequency lumbar stimulation.

We will apply these two techniques in combination with gait rehabilitation training to promote motor recovery in animal models of Parkinson’s disease and stroke. Collaborations within ReTune will allow us to interpret network plasticity at the neural, MRI and histological levels and to identify the circuits responsible for gait recovery using pharmacogenetic tools.

These conceptual foundations will facilitate the design of future clinical trials within ReTune.