Publications | ReTune

Real-world use and evaluation of a generative AI chatbot for Parkinson’s disease information: a prospective observational study

Lange, Mardi et al. 2026 Eur Lancet Reg Health

This study aimed to evaluate the real-world safety of a deployed patient-facing medical AI chatbot and to introduce CARE-LLM, a proposed framework for conversation-level post-market surveillance.

Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model

Hartig, Friedrich, Signoret-Genest et al. 2026 Nat Commun.

Postural and locomotor dysfunction represent axial symptoms of Parkinson’s disease (PD), which remain poorly treated by medication and deep brain stimulation. Whilst non-invasive neuromodulation of the vestibular system via the vestibular nucleus complex (VNC) offers a novel therapeutic avenue, the underlying circuits remain poorly characterized. Here we show that the mouse VNC feeds extensive Vglut2-defined projections into striato-thalamo-subthalamic and caudal medulla motor hubs and receives substantial input from the sensorimotor cortex. Optogenetic activation of excitatory VNC neurons increased cFos-based activity in basal ganglia-associated and brainstem motor targets. Pose dynamics and motion analysis showed enhanced behavioural modularity and locomotion. In a mouse model of PD, stimulation further favored naturalistic gait patterns through improved motor coordination. Our data identify excitatory VNC processes as candidates for therapeutic targeting of axial motor dysfunction in PD.

Neuroanatomical correlates of stroke-related dizziness and vertigo: secondary analysis from the INSPiRE-TMS trial

HJ, Kufner et al. 2026 J Neurol.

Dizziness and vertigo are common and debilitating neurological symptoms among patients visiting the emergency department (ED). Possibly because the symptoms are not captured by standard stroke severity tools such as the NIHSS (National Institutes of Health Stroke Scale), their network-level neuroanatomical correlates—particularly potential supratentorial contributions—remain incompletely characterized. Therefore, we aim to investigate the neuroanatomical substrates of post-stroke dizziness and vertigo.

Movement dependent neural substates within levodopa-induced dyskinesia in Parkinson’s disease

Habets et al. 2026 Brain

Parkinson patients suffer from levodopa-induced dyskinesia, which occur adversely to chronic dopaminergic treatment. These abnormal involuntary movements can only partly be actively suppressed and affect quality of life. A lowered motor inhibition during hyperdopaminergic states, associated with structural and plasticity changes in the cortico-basal-ganglia motor network, is hypothesized to enable dyskinesia. Multiple oscillatory cortico-subthalamic patterns associated with dyskinesia have been described but their dependence on behavioral states such as movement presence remains unknown, which is crucial for its use in real-life application of adaptive neuromodulation. We studied invasive cortico-subthalamic oscillations in 22 patients with Parkinson's disease during dyskinesia-evoking protocols.

Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization.

Groß et al. 2026 Angew Chem Int Ed Engl.

Hyperpolarized (HP) 13C nuclear magnetic resonance (NMR) spectroscopy enables real-time observation of metabolic fluxes but is typically limited to single-shot measurements due to complex preparation procedures and low experimental throughput. Here, we established a rapid and experimentally accessible workflow for temporally controlled HP measurements in living cells.

Who Falls After Stroke? Evidence From a Prospective Strohe Cohort.

Kufner, Tang et al. 2026 Eur J Neurol.

This study aimed to identify lesion-derived functional networks associated with impaired mobility, gait, and fall risk in subacute stroke, and to determine whether disruption to these networks is associated with falls during the six-month follow-up.