Chen J, Volkmann J, Ip CW.

NPJ Parkinsons Dis. 2024 Nov 8; 10(1): 216. doi: 10.1038/s41531-024-00829-5. Erratum in: NPJ Parkinsons Dis. 2025 Mar 4;11(1):40. doi: 10.1038/s41531-025-00890-8. PMID: 39516465; PMCID: PMC11549317.

Abstract

Deep brain stimulation (DBS) is an established treatment for motor disorders like Parkinson’s disease, but its mechanisms and effects on neurons and networks are not fully understood, limiting research-driven progress. This review presents a framework that combines neurophysiological insights and translational research to enhance DBS therapy, emphasizing biomarkers, device technology, and symptom-specific neuromodulation. It also examines the role of animal research in improving DBS, while acknowledging challenges in clinical translation.