Oct 28, 2025
Episode 2 of “ReTuneIn”: Modeling Deep Brain Stimulation – From Neural Networks to Digital Twins
In the third episode of the ReTune podcast “ReTuneIn”, neurologist and clinical scientist Dr. Lucia Feldmann and neurophysiologist Prof. Hagai Bergman discuss current advances in adaptive deep brain stimulation and the electrophysiological signals that guide it.
Dr. Feldmann, a Neurology Resident and Clinical Scientist at Charité Berlin, provides insights into how electrophysiological recordings are used to study Parkinson’s disease, with a particular focus on beta oscillations and how they change during sleep. Her work aims to understand how these rhythmic patterns reflect symptom severity and how they might inform next generation stimulation strategies.
Prof. Bergman contributes his long standing expertise in studying movement disorders and neuromodulation in non human primates. He highlights how controlled primate models allow researchers to disentangle physiological brain activity from artifacts and to investigate circuit level mechanisms that cannot be measured directly in humans. Together, Feldmann and Bergman explore the challenges of identifying robust biomarkers, the interpretation of oscillatory dynamics and the potential of closed loop systems that adjust stimulation based on real time feedback.
Episode 3 offers a comprehensive view of how electrophysiology, sleep research and primate neurophysiology jointly contribute to the development of adaptive DBS. The conversation shows how these approaches complement each other in the search for precise biomarkers and more responsive neuromodulation therapies.
Listen to Episode 3 now:
© Picture: TRR 295 ReTune
