Publications

We analysed subthalamic local field potentials from 119 patients with Parkinson's disease across five independent datasets. Power spectra were parametrised and studied in relation to Levodopa administration and the severity of motor symptoms.

These results suggest that, similar to sleep, the thalamic-cortical network, plays a crucial role in shaping basal ganglia activity during moderate sedation. EEG activity may, therefore, serve as a reference for selecting sedation protocols in deep brain stimulation procedures.

This study highlights that 1) homeodynamic cardiovascular control supports adaptive behavior under various states, 2)
higher-order brain regions orchestrate stressor-related cardiovascular changes and 3)
multidimensional approaches are crucial for understanding brain–heart interactions.

This study introduces [18F]DR29, a fluorine-18-labeled radiotracer for positron emission tomography imaging, to enable noninvasive visualization of AT1R expression. Its potential applications in understanding AT1R-associated renal processes are explored in healthy and hypertensive rat models.

Our approach, termed adaptive circuit targeting, decodes symptom severity from brain signals and adaptively activates the most relevant symptom-response circuits. We discuss the state of the art in the adaptive and connectomic DBS fields and the research gaps that need to be addressed to unify these concepts.

This review explores the current landscape of MPI, evaluates the clinical performance of novel 18F tracers, and discusses their transformative potential in expanding access to PET imaging and improving CAD diagnostics.