May 9, 2025 | 12 pm | Seminar room
Phil Starr & Coralie de Hemptinne
Gamma oscillations in the motor network in movement disorders.
In Parkinson’s disease, finely tuned gamma oscillations (FTG) (60-90 Hz) occur in the motor cortex, globus pallidus, and subthalamic nucleus. Their importance is underscored by the finding that att major categories of therapy for PD can induce gamma oscillations: levodopa (oral or intravenous), surgical lesioning of the pallidum, and neurostimulation. In the absence of stimulation, levodopa induced-FTG amplitude correlates with dyskinesia severity. In the cortex, globus pallidus and subthalamic nucleus, deep brain stimulation can entrain FTG to a subharmonic of the stimulation frequency. Entrainment by stimulation tends to mitigate the dyskinesia risk of levodopa-induced FTG, and may play a role in relief of bradykinesia. Entrained gamma oscillations are a useful marker of the medication-on state that can be used for adaptive DBS, with possible advantages over beta-driven adaptive DBS. The possible use of stimulation entrainment as an aid to DBS programming should be explored.
