Lange F, Guarin DL, Ademola E, Mahdy D, Acevedo G, Odorfer T, Wong JK, Volkmann J, Peach R, Reich M.

NPJ Parkinsons Dis. 2025 May 28;11(1):140. doi: 10.1038/s41531-025-00999-w. PMID: 40436873.

Abstract

We developed VisionMD, an AI computer vision platform, analyzing over 1200 clinical videos of Parkinson’s patients’ hand movements across 13 years. This large-scale, markerless analysis identified three kinematic domains (speed, consistency, timing/scale) reliably improved by levodopa. Our method offers objective, quantitative motor assessment, reducing subjectivity and enhancing reproducibility compared to traditional scales.