A translational perspective on pathophysiological changes of oscillatory activity in dystonia and parkinsonism.

Authors
Rauschenberger L, GĆ¼ttler C, Volkmann J, KĆ¼hn AA, Ip CW, Lofredi R.
Journal
Exp Neurol.

Review article

Abstract

Intracerebral recordings fromĀ movement disordersĀ patients undergoingĀ deep brain stimulationĀ have allowed the identification of pathophysiological patterns in oscillatory activity that correlate with symptom severity. Changes in oscillatory synchrony occur within and across brain areas, matching the classification of movement disorders as network disorders. However, the underlying mechanisms of oscillatory changes are difficult to assess in patients, as experimental interventions are technically limited and ethically problematic. This is why animal models play an important role in neurophysiological research of movement disorders. In this review, we highlight the contributions ofĀ translational researchĀ to the mechanistic understanding of pathological changes in oscillatory activity, with a focus onĀ parkinsonismĀ and dystonia, while addressing the limitations of current findings and proposing possible future directions.

Published: Sep 2022
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