Exact positioning of surgically-implanted electrodes is crucial to yield optimal outcomes for deep brain stimulation. To study the relationship between clinical outcomes and electrode placement across patients, we will employ and further advance the software tool Lead-DBS, which enables precise localization of DBS electrodes and modeling of their therapeutic effects.

We will perform electrode localizations for other projects within the CRC/TRR. This will also involve a novel pipeline for multimodal imaging and precise subcortical segmentation of target structures and advanced modeling of electric field distribution and neural activation.