November 23, 2023 | 5 pm | Hörsaal Innere Medizin
Rafal Bogacz
Selective entrainment of neural oscillations
Although deep brain stimulation is an established treatment for several neurological disorders, its effects on neural circuits are still not fully understood. It has been observed that the stimulation at high frequencies (e.g., 130Hz) may entrain and amplify oscillations with half frequency (e.g., 65Hz) that are related with movements. Such entrainment may cause side-effects of the treatment such as dyskinesia, and in such cases, it should be avoided. This talk will present simple mathematical models, which help understand why such entrainment arises, predict for what frequencies and amplitudes of stimulation it is likely to occur, and how the stimulation could be adjusted to avoid the undesired entrainment.
