Florin E, Kühn AA.
Nat Rev Neurol. 2026 Jun 29. doi: 10.1038/s41582-026-01239-2. Epub ahead of print. PMID: 42373954.
Abstract
Adaptive deep brain stimulation (DBS) promises to revolutionize the treatment of Parkinson disease with neuromodulation, and regulatory approval has enabled its use in clinical practice. This Clinical Outlook considers the principles behind adaptive DBS, current clinical recommendations and practical considerations in its implementation, as well as remaining challenges.
The regulatory approval of adaptive deep brain stimulation (DBS) for the treatment of Parkinson disease has enabled its implementation in routine clinical practice for real-time neuromodulation. By automatically adjusting stimulation amplitude on the basis of neural feedback signals, adaptive DBS represents a shift from conventional DBS, and moves from continuous neuromodulation to dynamic, state-dependent neuromodulation that can improve control of motor symptoms.
