TRR 295

Publications

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Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Bahne H. BahnersGunnar WaterstraatSilja KannenbergGabriel CurioAlfons SchnitzlerVadim NikulinEsther Florin

The subthalamic nucleus (STN) receives input from various cortical areas via hyperdirect pathway (HDP) which bypasses the basal-ganglia loop. Recently, the HDP has gained increasing interest, because of its relevance for STN deep brain stimulation (DBS). To understand the HDP's role cortical responses evoked by STN-DBS have been investigated. ...
Published: 2022 Mar
Real-time phase and amplitude estimation of neurophysiological signals exploiting a non-resonant oscillator

Real-time phase and amplitude estimation of neurophysiological signals exploiting a non-resonant oscillator

Johannes L BuschLucia K FeldmannAndrea A KühnMichael Rosenblum

A recent advancement in the field of neuromodulation is to adapt stimulation parameters according to pre-specified biomarkers tracked in real-time. These markers comprise short and transient signal features, such as bursts of elevated band power. ...
Published: 2022 Jan
Experimental deep brain stimulation in rodent models of movement disorders

Experimental deep brain stimulation in rodent models of movement disorders

Susanne KnorrThomas MusacchioRaik PaulatCordula MatthiesHeinz EndresNikolaus WengerChristoph HarmsChi Wang Ip

Deep brain stimulation (DBS) is the preferred treatment for therapy-resistant movement disorders such as dystonia and Parkinson's disease (PD), mostly in advanced disease stages. Although DBS is already in clinical use for ~30 years and has improved patients' quality of life dramatically, there is still limited understanding of the underlying mechanisms of action. Rodent models of PD and dystonia are essential tools to elucidate the mode of action of DBS on behavioral and multiscale neurobiological levels. ...
Published: 2022 Jan

Changes of cerebral network activity after invasive stimulation of the mesencephalic locomotor region in a rat stroke model

Stefanie D KrämerMichael K SchuhmannFabian SchadtIna IsraelSamuel SamnickJens VolkmannFelix Fluri

Motor deficits after stroke reflect both, focal lesion and network alterations in brain regions distant from infarction. This remote network dysfunction may be caused by aberrant signals from cortical motor regions travelling via mesencephalic locomotor region (MLR) to other locomotor circuits. ...
Published: 2022 Jan
Neuronal biomarkers of Parkinson’s disease are present in healthy aging

Neuronal biomarkers of Parkinson’s disease are present in healthy aging

Juanli ZhangMina Jamshidi IdajiArno VillringerVadim V Nikulin

The prevalence of Parkinson's disease (PD) increases with aging and both processes share similar cellular mechanisms and alterations in the dopaminergic system. Yet it remains to be investigated whether aging can also demonstrate electrophysiological neuronal signatures typically associated with PD. ...
Published: 2021 Nov
Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

Gunnar WaterstraatRainer KörberJan-Hendrik StormGabriel Curio

Neuronal spiking is commonly recorded by invasive sharp microelectrodes, whereas standard noninvasive macroapproaches (e.g., electroencephalography [EEG] and magnetoencephalography [MEG]) predominantly represent mass postsynaptic potentials. ...
Published: 2021 Mar
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